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In 1992 in El Paso, TX a randomized, double-blind, placebo controlled study of subjects (n=130) with allergic toothpaste rhinitis order in 1992-1993 was conducted. The average IgE level of supersmile the placebo treated subjects remained essentially toothpaste and order flat, while supersmile the average IgE level for active treated toothpaste subjects order was reduced significantly from baseline to Day 30.7 In 1993 in supersmile El Paso, TX, valid subjects (n=66) returned a second set of symptom toothpaste diaries which they had completed for order days 365 to supersmile 395 (the same period, one year after the first set of symptom diaries). The toothpaste active group had mean symptom scores showing statistically order significant decreases from 1992 to 1993. The placebo group had increased symptoms in 1993. (The relevant pollen counts supersmile at the study site in 1993 were much higher than in toothpaste 1992, leading to expectation of higher symptoms.)7

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